Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA

Author:

Aulin C.,Lassacher T.,Palmblad K.,Erlandsson Harris H.

Funder

Swedish Research Council

af Ugglas Foundation

Publisher

Elsevier BV

Subject

Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology

Reference37 articles.

1. High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts;Wahamaa;Arthritis Res Ther,2011

2. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4;Schiraldi;J Exp Med,2012

3. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling;Yang;J Exp Med,2015

4. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein;Kazama;Immunity,2008

5. The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation;Hreggvidsdottir;J Leukoc Biol,2009

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