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Multi-layered genetic approaches to identify approved drug targets

Published:2023-07 Issue:7 Volume:3 Page:100341
ISSN:2666-979X
Container-title:Cell Genomics
language:en
Short-container-title:Cell Genomics

Author:

Sadler Marie C.^ORCID,Auwerx Chiara,Deelen Patrick,Kutalik Zoltán

Funder

Université de Lausanne

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Elsevier BV

Subject

Genetics,Biochemistry, Genetics and Molecular Biology (miscellaneous)

Reference66 articles.

1. The support of human genetic evidence for approved drug indications;Nelson;Nat. Genet.,2015

2. Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval;King;PLoS Genet.,2019

3. Beyond GWASs: illuminating the dark road from association to function;Edwards;Am. J. Hum. Genet.,2013

4. GWAS and drug targets;Cao;BMC Genom.,2014

5. Benefits and limitations of genome-wide association studies;Tam;Nat. Rev. Genet.,2019

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4. Multi-omics characterization of type 2 diabetes associated genetic variation;2024-07-15

5. Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease;iScience;2024-07

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