Targeting oncogenic WIP1 phosphatase sensitizes hypoxic breast cancer cells to doxorubicin induced apoptosis via activation of p53-p21 axis
Author:
Funder
TÜBİTAK
Adnan Menderes University
Publisher
Elsevier BV
Subject
Genetics
Reference24 articles.
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2. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response;Cha;Cancer Res.,2010
3. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner;Fiscella;Proc. Natl. Acad. Sci.,1997
4. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase;Fujimoto;Cell Death Differ.,2006
5. DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase. IX;Kaluzová;Mol. Cell. Biol.,2004
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Wip1 phosphatase inhibition enhances etoposide mediated apoptosis by increasing p53 phosphorylation in Rhabdoid tumor cells;Gene Reports;2023-06
2. Hypoxia-Regulated Gene Expression and Metastasis;Hypoxia in Cancer: Significance and Impact on Cancer Therapy;2023
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