Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers

Author:

Kågedal Matts,Cselényi Zsolt,Nyberg Svante,Jönsson Siv,Raboisson Patrick,Stenkrona Per,Hooker Andrew C.,Karlsson Mats O.

Publisher

Elsevier BV

Subject

Cognitive Neuroscience,Neurology

Reference21 articles.

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2. Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy;Abanades;J. Cereb. Blood Flow Metab.,2011

3. Andersson, J., 2010, Development of PET Radioligands Synthesized from In-Target Produced [11C]Methane. Thesis, (PhD). Karolinska Institutet. (Paper III).

4. NONMEM User's Guides,1989

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