Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons-Reference-Cited by-同舟云学术

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Published:2019-03 Issue:3 Volume:24 Page:363-375.e9
ISSN:1934-5909
Container-title:Cell Stem Cell
language:en
Short-container-title:Cell Stem Cell

Author:

van der Kant Rik,Langness Vanessa F.,Herrera Cheryl M.,Williams Daniel A.,Fong Lauren K.,Leestemaker Yves,Steenvoorden Evelyne,Rynearson Kevin D.,Brouwers Jos F.,Helms J. Bernd,Ovaa Huib,Giera Martin,Wagner Steven L.,Bang Anne G.,Goldstein Lawrence S.B.

Funder

Alzheimer Netherlands

ERC Marie Curie

NIH

NIA

CIRM

Publisher

Elsevier BV

Subject

Cell Biology,Genetics,Molecular Medicine

Reference74 articles.

1. Mapping of the allosteric site in cholesterol hydroxylase CYP46A1 for efavirenz, a drug that stimulates enzyme activity;Anderson;J. Biol. Chem.,2016

2. Efavirenz: what is known about the cellular mechanisms responsible for its adverse effects;Apostolova;Eur. J. Pharmacol.,2017

3. Lipid droplets as signaling platforms linking metabolic and cellular functions;Arrese;Lipid Insights,2014

4. The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol;Barrett;Science,2012

5. Profiling proteasome activity in tissue with fluorescent probes;Berkers;Mol. Pharm.,2007

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3. Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease;eBioMedicine;2024-08

4. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference;Alzheimer's & Dementia;2024-07-19

5. Cholesterol Metabolism in Neurodegenerative Diseases;Antioxidants & Redox Signaling;2024-07-11

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