Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity-Reference-Cited by-同舟云学术

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Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

Published:2016-05 Issue:22 Volume:291 Page:11876-11886
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Anderson Kyle W.,Mast Natalia,Hudgens Jeffrey W.,Lin Joseph B.,Turko Illarion V.,Pikuleva Irina A.

Funder

U.S. Public Health Service

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference35 articles.

1. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24s-hydroxycholesterol from the brain into the circulation;Lütjohann;Proc. Natl. Acad. Sci. U.S.A,1996

2. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain;Lund;Proc. Natl. Acad. Sci. U.S.A,1999

3. cholesterol homeostasis in human brain: turnover of 24s-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation;Björkhem;J. Lipid Res,1998

4. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover;Lund;J. Biol. Chem,2003

5. Brain cholesterol turnover required for geranylgeraniol production and learning in mice;Kotti;Proc. Natl. Acad. Sci. U.S.A,2006

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4. 7,8-Dihydroxy Efavirenz Is Not as Effective in CYP46A1 Activation In Vivo as Efavirenz or Its 8,14-Dihydroxy Metabolite;International Journal of Molecular Sciences;2024-02-13

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