Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models

Author:

Beaumont Vahri,Zhong Sheng,Lin Hai,Xu WenJin,Bradaia Amyaouch,Steidl Esther,Gleyzes Melanie,Wadel Kristian,Buisson Bruno,Padovan-Neto Fernando E.,Chakroborty Shreaya,Ward Karen M.,Harms John F.,Beltran Jose,Kwan Mei,Ghavami Afshin,Häggkvist Jenny,Tóth Miklós,Halldin Christer,Varrone Andrea,Schaab Christoph,Dybowski J. Nikolaj,Elschenbroich Sarah,Lehtimäki Kimmo,Heikkinen Taneli,Park Larry,Rosinski James,Mrzljak Ladislav,Lavery Daniel,West Anthony R.,Schmidt Christopher J.,Zaleska Margaret M.,Munoz-Sanjuan Ignacio

Funder

CHDI Foundation, Inc.

Pfizer, Inc.

Publisher

Elsevier BV

Subject

General Neuroscience

Reference50 articles.

1. PET imaging shows loss of striatal PDE10A in patients with Huntington disease;Ahmad;Neurology,2014

2. Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington’s disease;Albin;Ann. Neurol.,1992

3. Large-scale phenome analysis defines a behavioral signature for Huntington’s disease genotype in mice;Alexandrov;Nat. Biotechnol.,2016

4. The PDE1/5 inhibitor SCH-51866 does not modify disease progression in the R6/2 mouse model of Huntington’s disease;Beaumont;PLoS Curr.,2014

5. Refining the diagnosis of Huntington disease: the PREDICT-HD study;Biglan;Front. Aging Neurosci.,2013

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