Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice-Reference-Cited by-同舟云学术

Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice

Published:2016-07-04 Issue:8 Volume:34 Page:838-844
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Alexandrov Vadim,Brunner Dani,Menalled Liliana B,Kudwa Andrea,Watson-Johnson Judy,Mazzella Matthew,Russell Ian,Ruiz Melinda C,Torello Justin,Sabath Emily,Sanchez Ana,Gomez Miguel,Filipov Igor,Cox Kimberly,Kwan Mei,Ghavami Afshin,Ramboz Sylvie,Lager Brenda,Wheeler Vanessa C,Aaronson Jeff,Rosinski Jim,Gusella James F,MacDonald Marcy E,Howland David,Kwak Seung

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.3587.pdf

Reference47 articles.

1. Denny, J.C. et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat. Biotechnol. 31, 1102–1110 (2013).

2. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971–983 (1993).

3. Langbehn, D.R., Hayden, M.R. & Paulsen, J.S. CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 153B, 397–408 (2010).

4. Craufurd, D. & Dodge, A. Mutation size and age at onset in Huntington's disease. J. Med. Genet. 30, 1008–1011 (1993).

5. Raymond, L.A. et al. Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience 198, 252–273 (2011).

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