Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway

Author:

Dal-Cim Tharine,Molz Simone,Egea Javier,Parada Esther,Romero Alejandro,Budni Josiane,Martín de Saavedra Maria D.,Barrio Laura del,Tasca Carla I.,López Manuela G.

Funder

Spanish Ministry of Science and Innovation

Ministry of Education

Spanish Ministry of Health (Instituto de Salud Carlos III)

Publisher

Elsevier BV

Subject

Cell Biology,Cellular and Molecular Neuroscience

Reference65 articles.

1. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway;Alam;Curr. Pharm. Des.,2003

2. Biliverdin reductase: a major physiologic cytoprotectant;Baranano;Proc. Natl. Acad. Sci. USA,2002

3. Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP;Bau;Purinergic Signal.,2005

4. The neuroprotective activity of guanosine involves the production of trophic factors and the outflow of purines from astrocytes;Caciagli;Drug Dev. Res.,2000

5. Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt;Cañas;J. Pharmacol. Exp. Ther.,2007

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