Evaluation of capillary electrophoresis-mass spectrometry for the analysis of the conformational heterogeneity of intact proteins using beta2-microglobulin as model compound

Author:

Bertoletti Laura,Schappler Julie,Colombo Raffaella,Rudaz Serge,Haselberg Rob,Domínguez-Vega Elena,Raimondi Sara,Somsen Govert W.,De Lorenzi Ersilia

Funder

Italian Ministry of University and Research

Progetto Regione Lombardia

Publisher

Elsevier BV

Subject

Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference48 articles.

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3. Protein misfolding, functional amyloid, and human disease;Chiti;Annu. Rev. Biochem.,2006

4. A generic mechanism of beta2-microglobulin amyloid assembly at neutral pH involving a specific proline switch;Eichner;J. Mol. Biol.,2009

5. A partially structured species of beta 2-microglobulin is significantly populated under physiological conditions and involved in fibrillogenesis;Chiti;J. Biol. Chem.,2001

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