Simultaneous determination of a novel thrombin inhibitor and its two metabolites in human plasma by liquid chromatography/tandem mass spectrometry
Author:
Publisher
Elsevier BV
Subject
Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry
Reference10 articles.
1. Identification and SAR for a selective, nonpeptidyl thrombin inhibitor
2. Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
3. Small, noncovalent serine protease inhibitors
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1. Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif;Journal of Medicinal Chemistry;2010-01-26
2. Direct thrombin inhibitors – a survey of recent developments;Cellular and Molecular Life Sciences;2006-11-13
3. Progress in the Development of Synthetic Thrombin Inhibitors as New Orally Active Anticoagulants;Current Medicinal Chemistry;2004-09-01
4. Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines;Journal of Medicinal Chemistry;2003-01-08
5. Determination of ximelagatran, an oral direct thrombin inhibitor, its active metabolite melagatran, and the intermediate metabolites, in biological samples by liquid chromatography–mass spectrometry;Journal of Chromatography B;2003-01
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