Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp-Reference-Cited by-同舟云学术

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Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp

Published:2008-03-01 Issue:3 Volume:154 Page:744-755
ISSN:1350-0872
Container-title:Microbiology
language:en
Short-container-title:

Author:

Gomez-Escribano Juan P.¹,Martín Juan F.²¹,Hesketh A.³,Bibb M. J.³,Liras P.²¹

Affiliation:

1. Área de Microbiología, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain

2. Instituto de Biotecnología (INBIOTEC), Parque Científico de León, Av. Real 1, 24006 León, Spain

3. Department of Molecular Microbiology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK

Publisher

Microbiology Society

Subject

Microbiology

Reference42 articles.

1. Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus;Bascarán;J Gen Microbiol,1991

2. Expression of ccaR , encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus , is dependent on bldG;Bignell;Antimicrob Agents Chemother,2005

3. New horizons for (p)ppGpp in bacterial and plant physiology;Braeken;Trends Microbiol,2006

4. Determination of DNA concentration with diphenylamine;Burton;Methods Enzymol,1968

5. The control of ribonucleic acid synthesis in Escherichia coli . Characterization of a nucleotide associated with the stringent response;Cashel;J Biol Chem,1970

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1. ppGpp is a dual‐role regulator involved in balancing iron absorption and prodiginine biosynthesis in Pseudoalteromonas;Molecular Microbiology;2024-06-06

2. Physiology and Transcriptional Analysis of ppGpp-Related Regulatory Effects in Streptomyces diastatochromogenes 1628;Microbiology Spectrum;2023-02-14

3. Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus;Microbial Genomics;2021-11-05

4. Streptomyces clavuligerus: The Omics Era;Journal of Industrial Microbiology and Biotechnology;2021-10-02

5. Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus;Protein & Peptide Letters;2021-03-22

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