Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor-Reference-Cited by-同舟云学术

Chimpanzee adenovirus CV-68 adapted as a gene delivery vector interacts with the coxsackievirus and adenovirus receptor

Published:2002-01-01 Issue:1 Volume:83 Page:151-155
ISSN:0022-1317
Container-title:Journal of General Virology
language:en
Short-container-title:

Author:

Cohen Christopher J.¹,Xiang Zhi Quan²,Gao Guang-Ping³,Ertl Hildegund C. J.²,Wilson James M.³²,Bergelson Jeffrey M.¹

Affiliation:

1. The Children’s Hospital of Philadelphia, Division of Immunologic and Infectious Diseases, Abramson 1202, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA1

2. The Wistar Institute, Philadelphia, PA 19104, USA2

3. The Institute for Human Gene Therapy, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA3

Abstract

A replication-defective form of chimpanzee adenovirus type 68 (C68) has been developed to circumvent problems posed by widespread preexisting immunity to common human adenovirus vectors. To investigate the determinants of C68 tropism, its interaction with the coxsackievirus and adenovirus receptor (CAR) was studied. Although CHO cells were resistant to transduction by C68 as well as by adenovirus type 5 (Ad5), CHO cells expressing either human or murine CAR were transduced readily. C68 transduction, like Ad5 transduction, was blocked when cells were exposed to anti-CAR antibody or when virus was exposed to a soluble form of the CAR extracellular domain. These results indicate that gene delivery by C68 occurs by a CAR-dependent mechanism.

Publisher

Microbiology Society

Subject

Virology

Reference26 articles.

1. Adenovirus type 37 uses sialic acid as a cellular receptor;Arnberg;Journal of Virology,2000

2. Characterization of four new adenovirus serotypes isolated from chimpanzee tissue explants;Basnight;American Journal of Epidemiology,1971

3. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5;Bergelson;Science,1997

4. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR;Bewley;Science,1999

5. A replication defective vector based on a chimpanzee adenovirus;Farina;Journal of Virology,2001

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A modified recombinant adenovirus vector containing dual rabies virus G expression cassettes confers robust and long-lasting humoral immunity in mice, cats, and dogs;Emerging Microbes & Infections;2024-01-22

2. Seroprevalence of human adenovirus type 5 neutralizing antibodies in the Philippines;PLOS ONE;2023-12-01

3. Adenoviral Vector-Based Vaccine Platform for COVID-19: Current Status;Vaccines;2023-02-13

4. Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines;Current Opinion in Immunology;2023-02

5. Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment;Vaccine;2022-08