Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates

Author:

Gladstone Rebecca A.1ORCID,Lo Stephanie W.1ORCID,Goater Richard23,Yeats Corin23ORCID,Taylor Ben23ORCID,Hadfield James4,Lees John A.5ORCID,Croucher Nicholas J.5,van Tonder Andries J.61ORCID,Bentley Leon J.1,Quah Fu Xiang1ORCID,Blaschke Anne J.7ORCID,Pershing Nicole L.7ORCID,Byington Carrie L.8,Balaji Veeraraghavan9,Hryniewicz Waleria10,Sigauque Betuel11,Ravikumar K.L.12,Almeida Samanta Cristine Grassi13,Ochoa Theresa J.14ORCID,Ho Pak Leung15ORCID,du Plessis Mignon16ORCID,Ndlangisa Kedibone M.16,Cornick Jennifer E.17,Kwambana-Adams Brenda1819ORCID,Benisty Rachel20,Nzenze Susan A.2122,Madhi Shabir A.2122,Hawkins Paulina A.23,Pollard Andrew J.24ORCID,Everett Dean B.25,Antonio Martin18,Dagan Ron20,Klugman Keith P.23,von Gottberg Anne15ORCID,Metcalf Benjamin J.26ORCID,Li Yuan26,Beall Bernard W.26,McGee Lesley26ORCID,Breiman Robert F.2723,Aanensen David M.23,Bentley Stephen D.1ORCID,

Affiliation:

1. Parasites and microbes, Wellcome Sanger InstituteHinxton, UK

2. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK

3. Centre for Genomic Pathogen Surveillance, Wellcome Genome CampusHinxton, UK

4. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

5. Faculty of Medicine, School of Public Health, Imperial College London, UK

6. Department of Veterinary Medicine, University of Cambridge, Cambridge, UK

7. Division of Pediatric Infectious Diseases, Department of Pediatrics, School of Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84108, USA

8. University of California Health, Oakland, CA, USA

9. Christian Medical College, Vellore, India

10. National Medicines Institute, Division of Clinical Microbiology and Infection Prevention, Warsaw, Poland

11. Fundação Manhiça / Centro de Investigação em Saúde da Manhiça (CISM), Maputo Mozambique, Instituto Nacional de Saúde, inistério de Saúde, Maputo, Mozambique

12. Central Research Laboratory, Department of Microbiology, Kempegowda Institute of Medical Sciences Hospital & Research Center, Bangalore, India

13. Center of Bacteriology, Adolfo Lutz Institute, São Paulo, Brazil

14. Instituto de Medicina Tropical, Universidad Peruana Cayetano Heredia, Lima, Peru

15. Department of Microbiology and Carol Yu Centre for Infection, The University of Hong Kong, Queen Mary Hospital, Hong Kong, PR China

16. Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa

17. Malawi-Liverpool-Wellcome-Trust, Malawi

18. WHO Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at The London School of Hygiene & Tropical Medicine, Fajara, The Gambia

19. NIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection and Immunity, University College London, London, UK

20. The Faculty of Health Sciences, Ben-Gurion University of the NegevBeer-Sheva, Israel

21. Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa

22. Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa

23. Rollins School Public Health, Emory University, GA, USA

24. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK

25. Queens Research Institute, University of Edinburgh, UK

26. Centers for Disease Control and Prevention, Atlanta, GA, USA

27. Emory Global Health Institute, Atlanta, GA, USA

Funder

Bill and Melinda Gates Foundation

Publisher

Microbiology Society

Subject

General Medicine

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