Fidaxomicin has high in vitro activity against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Fidaxomicin has high in vitro activity against Mycobacterium tuberculosis

Published:2021-03-01 Issue:3 Volume:70 Page:
ISSN:0022-2615
Container-title:Journal of Medical Microbiology
language:en
Short-container-title:

Author:

Sun Qing¹,Wang Shuqi¹,Liao Xinlei¹,Jiang Guanglu¹,Huang Hairong¹,Li Hao²³^ORCID,Wang Guirong¹

Affiliation:

1. National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, PR China

2. College of Veterinary Medicine, China Agricultural University, Beijing, PR China

3. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, PR China

Abstract

This study aimed to evaluate whether the antibiotic fidaxomicin has in vitro activity against

Mycobacterium tuberculosis

(Mtb). 38 fully drug-sensitive Mtb strains and 34 multidrug-resistant tuberculosis (MDR-TB) strains were tested using the microplate alamar blue assay (MABA) method to determine the minimum inhibitory concentrations (MICs) for fidaxomicin and rifampicin. Fidaxomicin has high in vitro activity against Mtb and is a potential drug to treat Mtb, and MDR-TB infections in particular.

Funder

National Natural Science Foundation of China

National Major Science and Technology Projects of China

Beijing Talents foundation

Tongzhou Yunhe Project

Publisher

Microbiology Society

Subject

Microbiology (medical),General Medicine,Microbiology

Reference12 articles.

1. Global tuberculosis report,2020

2. Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis