Abstract
Biodegradable and biohybrid materials for nanobioelectronics offer a compelling alternative for developing next-generation brain-computer interfaces (BCIs). In this chapter, we focus on the critical need for biodegradability within nanobioelectronics and the advent of biohybrid materials as key solutions for integrating biological and synthetic components. A thorough exploration of biodegradation mechanisms, encompassing solubilization, chemical hydrolysis, and enzymatic processes, underscores the intricate pathways involved. Additionally, we investigate the utilization of biodegradable materials across bioresorbable devices such as neural interfaces, drug carrier electrodes, and intracranial pressure monitors. Moreover, we delve into the integration of living microorganisms with synthetic compounds to develop biohybrid materials, explaining their potential for enhancing functionality and biocompatibility in neural interfaces. Design considerations for both biodegradable and biohybrid devices are examined, addressing challenges and proposing strategic approaches for mitigation. Finally, we conclude with a forward-looking perspective on the future trajectory of BCIs, emphasizing the importance of ongoing research and innovation to boost the field forward.