Formation, Regulation, and Eradication of Bacterial Biofilm in Human Infection

Abstract

Microbial biofilms are complicated structures in which planktonic cells change to a sessile form of growth. The development of an extracellular polymeric substance (EPS) matrix, which encloses the bacterial cells and offers additional protection, supports that kind of growth. Biofilms present a significant threat to public health due to their extreme resistance to higher antibiotic concentrations. In addition, biofilms are also resistant to human immune systems. Bacterial biofilms can spread their pathogenicity through a variety of approaches, such as adhering to a solid surface, evading host defenses like phagocytosis, generating a large amount of toxins, resisting anti-microbial agents, transferring genes to generate more virulent strains, and dispersing microbial aggregates that transport the microorganisms to new locations. Consequently, there is an urgent need to replace the widespread procedure of antibiotics with novel developing approaches. Furthermore, biofilm formation has been connected with high rates of disease, health-related infections, and even death, leading to the search for alternative treatment approaches. The review intends to provide information about clinically important bacterial pathogens of the gut, mouth, skin, and lungs and insights into the different perceptions of microbial biofilms, as well as their formation, regulation, and pathogenicity. In addition, for efficient eradication or inhibition of biofilms and associated infections, nanoparticle approaches for addressing persistent bacterial infections have also been discussed.