Resveratrol Synthesis, Metabolism, and Delivery: A Mechanistic Treatise

Abstract

Resveratrol, a bioactive phytochemical classified as a phytoalexin present in plant sources, is recognized for its distinct characteristics such as anticancer, chemoprotective, chemosensitizer, neuroprotective, anti-inflammatory, and antioxidant properties. Resveratrol is a polyphenol that increases the susceptibility of cancer-resistant cells to chemotherapy. Resveratrol also aids in weight loss by decreasing lipogenesis, the prevention of neurological illnesses, and other topical uses such as the treatment of skin hyperpigmentation. During the past 10 years, resveratrol, a naturally occurring stilbene found in various foods and drinks, has drawn increased interest due to its many health benefits, including its chemo-preventive and anticancer actions. Several naturally occurring resveratrol derivatives can be found in food and share a similar structural makeup with resveratrol. To boost the effectiveness and activity of particular resveratrol features, several resveratrol analogues have also been created by the addition of designated functional groups. Such resveratrol derivatives might provide beneficial cancer therapeutics and cancer chemo-preventive drugs for cancer prevention and therapy. However, the quest for the identification of new analogues with high yield must be explored to extend resveratrol effectiveness. This chapter provides an overview of the most significant resveratrol derivatives used to treat cardiovascular diseases and the methods of their synthesis.