A New Angular Naphthopyrone from Crinoid Colobometra perspinosa

Author:

Chung Hsu-Ming,Hsiao Ling-Tsung,Li Zong-You,Wen Zhi-Hong

Abstract

A chemical investigation was carried out on a crinoid Colobometra perspinosa collected from Hengchun Peninsula in the South China Sea, which led to the isolation of five angular naphthopyrones (1–5), including one new metabolite, 8-hydroxy-5,6,10-trimethoxy-2-pentyl-4H-naphtho[1,2-b]pyran-4-one (1). Their structures were assigned based on spectroscopic methods, including UV, HRESIMS, 1D- and 2D-NMR spectra. The anti-inflammatory activity of the isolated compounds was evaluated and compound 5 was found to inhibit the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophages.

Publisher

ACG Publications

Subject

Organic Chemistry,Plant Science,Drug Discovery,Pharmacology

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