Author:
Jackson Timothy W.,Kojima Masaharu,Lambrecht Richard M.
Abstract
The chemistry and physical properties of a series of rhenium diamino dithiol
(dadt) complexes are described. Liposolubility was enhanced by
N-substitution of alkyl chains of
C1–C14 length on one ligand
structure, with longer chain lengths showing the higher solubility, but with a
reduction of radiolabelling yield with 99mTc and
186Re. Among the ReV=O
[dadt] complexes synthesized, we found that
2,2,9,9-tetramethyl-4-N-alkyl-4,7-diaza-1,10-decanedithiol
(alkyl = C1–C10)
resulted in stable and lipiodol-soluble complexes. Biological characteristics
of the C6 ligand labelled with
99mTc and 186Re were compared, and
indicated that the complexes behaved in a similar manner in rodents. The dadt
ligands in combination with 188Re or
186Re and fatty acid oils merit further consideration as
endotherapeutic radiopharmaceuticals for treatment of hepatoma and metastatic
liver cancer.
Cited by
7 articles.
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