Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates-Reference-Cited by-同舟云学术

Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

Published:2019 Issue:8 Volume:10 Page:1370-1378
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Liu Chun-Mei¹²³⁴,Huang Jia-Yan¹²³⁴,Sheng Li-Xin¹²³⁴,Wen Xiao-An⁵⁶⁷⁸⁹,Cheng Ke-Guang¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmacy of Guangxi Normal University

3. Guilin 541004

4. PR China

5. Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases and

6. State Key Laboratory of Natural Medicines

7. Center of Drug Discovery

8. China Pharmaceutical University

9. Nanjing 210009

Abstract

Due to the obvious adverse effects of 5-fluorouracil and considering the diverse biological activities of pentacyclic triterpenes, twelve pentacyclic triterpene-5-fluorouracil conjugates were synthesized and their antitumor activities were evaluated.

Funder

National Natural Science Foundation of China

Guangxi Normal University

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00246D

Reference38 articles.

1. A rapid albumin-binding 5-fluorouracil prodrug with a prolonged circulation time and enhanced antitumor activity