Synthesis of Some 4-Oxothiochromenes and Related Compounds

Abstract

Thiosalicylic acids react with 2-substituted N,N-dialkyl acetamides to give 3-substituted-N,N-dialkyl-2-amino-4-oxothiochromenes 13. N-Alkyl 2-piperidone and analogous caprolactams give derivatives of 1,2,3,4-tetrahydrothiochromeno[2,3-b]pyridin-5-one 16a–16d and 7,8,9,10-tetrahydro-6H-5-thia-6-aza-cyclohepta-[b]naphthalen-11-one 16e, 16f. 2-Mercaptonicotinic acid gave a 1,2,3,4-tetrahydro-9-thia-1,8-diazaanthracen-10-one 16g and a 1,2,3,4-tetrahydro-9-thia-1,8-diazaanthracene-10-thione 16h.