Author:
Sun Q. Y.,Breitbart H.,Schatten H.
Abstract
The mitogen-activated protein kinase (MAPK) cascade is one of the most
important of the intracellular signaling pathways that play a crucial role in
cell proliferation, cell differentiation and cell cycle regulation. Since the
first report in 1993 of MAPK’s involvement in the functional regulation
of mammalian oocytes, much work has been done on the role of the MAPK cascade
in germ cells in different species of mammals. This review describes the
possible involvement of the MOS/MEK/MAPK/RSK cascade in
spermatogenesis, sperm function, oocyte meiotic re-initiation, spindle
assembly, metaphase II arrest, pronuclear formation and the entry of first
mitosis, as well as the cross-talk of this cascade to maturation-promoting
factor (MPF) and other signal molecules in mammals.
Subject
Developmental Biology,Endocrinology,Genetics,Molecular Biology,Animal Science and Zoology,Reproductive Medicine,Biotechnology
Cited by
85 articles.
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