Author:
Stunzi H,Harris LN,Perrin DD,Teitei T
Abstract
Stability constants for the
Mg2+, Ca2+, Cu2+ and Zn2+ complexes
of two isomers (2) and (3) of the defleecing agent mimosine (1) have been
sought from potentiometric titrations in aqueous
solution, 0.15 M KNO3, at 37°. For the interpretation of the
results, complex formation of the simpler ligands 3-hydroxypyridin-4(1H)-one
(4), its 2-oxo isomer (5) and
DL-α-amino-β-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid (6) was
studied. The results with ligand (2) are very similar to those with mimosine,
for which a computer blood-plasma model indicates metal chelation under
physiological conditions. Ligand (3) is a much weaker complexing agent.
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