THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

Author:

Rathmell Jeffrey C.1,Thompson Craig B.1

Affiliation:

1. Gwen Knapp Center for Lupus and Immunology Research, Department of Medicine, and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637;

Abstract

▪ Abstract  The immune system relies on cell death to maintain lymphoid homeostasis and avoid disease. Recent evidence has indicated that the caspase family of cysteine proteases is a central effector in apoptotic cell death and is absolutely responsible for many of the morphological features of apoptosis. Cell death, however, can occur through caspase-independent and caspase-dependent pathways. In the case of cells that are irreversibly neglected or damaged, death occurs even in the absence of caspase activity. In contrast, healthy cells require caspase activation to undergo cell death induced by surface receptors. This review summarizes the current understanding of these two pathways of cell death in the immune system.

Publisher

Annual Reviews

Subject

Immunology,Immunology and Allergy

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