Phase Separation in Biological Membranes: Integration of Theory and Experiment

Author:

Elson Elliot L.1,Fried Eliot2,Dolbow John E.3,Genin Guy M.4

Affiliation:

1. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, and Department of Physics, Washington University, St. Louis, Missouri 63110;

2. Department of Mechanical Engineering, McGill University, Montreal, Quebec H3A 2T5, Canada

3. Computational Mechanics Laboratory, and Department of Civil Engineering, Duke University, Durham, North Carolina 27708

4. Department of Mechanical, Aerospace, and Structural Engineering, Washington University, St. Louis, Missouri 63130

Abstract

Lipid bilayer model membranes that contain a single lipid species can undergo transitions between ordered and disordered phases, and membranes that contain a mixture of lipid species can undergo phase separations. Studies of these transformations are of interest for what they can tell us about the interaction energies of lipid molecules of different species and conformations. Nanoscopic phases (<200 nm) can provide a model for membrane rafts, specialized membrane domains enriched in cholesterol and sphingomyelin, which are believed to have essential biological functions in cell membranes. Crucial questions are whether lipid nanodomains can exist in stable equilibrium in membranes and what is the distribution of their sizes and lifetimes in membranes of different composition. Theoretical methods have supplied much information on these questions, but better experimental methods are needed to detect and characterize nanodomains under normal membrane conditions. This review summarizes linkages between theoretical and experimental studies of phase separation in lipid bilayer model membranes.

Publisher

Annual Reviews

Subject

Cell Biology,Biochemistry,Bioengineering,Structural Biology,Biophysics

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