Author:
Deeksha Maletha ,Satya Pal Singh ,S RAMANARAYANAN
Abstract
The current research work was undertaken to evaluate the hepatoprotective and nephroprotective potential of Cichorium intybus following subchronic exposure of imidacloprid in white leghorn (WLH) chicks. Thirty, 6 to 8 weeks old chicks of 300-350 g weight were randomly and equally divided into five groups. Group I served as control and was fed normal grower ration and other were fed medicated ration containing Cichorium intybus leaf powder @ 5000 ppm in Group II, imidacloprid @ 100 ppm in Group III, imidacloprid @ 100 ppm + silymarin @ 100 ppm in Group IV and imidacloprid @ 100 ppm + Cichorium intybus leaf powder @ 5000 ppm in Group V, respectively, for 8 weeks. Biochemical parameters at 4th and 8th week revealed a significant increase in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase, lactate dehydrogenase, total bilirubin, indirect bilirubin, creatinine, blood urea nitrogen (BUN) with an increase in absolute and relative organ weights of liver and kidney after 8 weeks and a significant decline in total protein, albumin and globulin in imidacloprid treated Group III as compared to control (Group I). However, the simultaneous administration of Cichorium intybus leaf powder (CILP) in Group V revealed amelioration in these parameters at par with Groups I and IV. Thus, amelioration of imidacloprid induced hepatotoxic and nephrotoxic effects following simultaneous CILP administration indicates hepatoprotective and nephroprotective potential of Cichorium intybus in imidacloprid intoxicated cockerels.
Publisher
Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
Subject
General Veterinary,Animal Science and Zoology
Reference45 articles.
1. Abd-Elhakim Y, Mohammed H H and Mohamed W A. 2018. Imidacloprid impacts on neurobehavioral performance,
2. oxidative stress, and apoptotic events in the brain of adolescent and adult rats. Journal of Agricultural and Food Chemistry 66(51): 13513–24.
3. Abu Zeid E H, Alam R T H, Ali S A and Hendawi M Y. 2019. Dose-related impacts of imidacloprid oral intoxication on brain and liver of rock pigeon (Columba livia domestica), residues analysis in diferent organs. Ecotoxicology and Environmental Safety 167: 60–68.
4. Al-Snafi A E. 2016. Medical importance of Cichorium intybus: A review. IOSR Journal of Pharmacy 6: 41–56. Aly H A, Lightfoot D A and El-Shemy H A. 2009. Modulatory role of lipoic acid on lipopolysaccharide induced oxidative
5. stress in adult rat sertoli cells in vitro. Chemico-Biological Interactions 182(2): 112–18.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献