Affiliation:
1. Research Institute for Complex Issues in Cardiovascular Diseases (RICICD); Kemerovo State Medical University (KemSTU)
2. Research Institute for Complex Issues in Cardiovascular Diseases (RICICD)
Abstract
The immune system in critical illnesses initiates local inflammation in the damaged area. In the absence of a balance between local and systemic inflammations, an infectious or non-infectious systemic inflammatory response follows, which has a stage of "hyper inflammation - compensatory anti-inflammatory response", that may result in multi-organ failure. The final stage of critical ill-nesses, therefore, will be characterized by induced immunosuppression with the impaired function of neutrophils, monocytes, macrophages and dendritic cells and release of myeloid-derived suppres-sor cells. The aim of the review is to evaluate the contribution of various components of the im-mune response to the formation of induced immune suppression from the perspective of candidate diagnostic markers.
Publisher
Siberian State Medical University
Cited by
7 articles.
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