Abstract
It has been well-established that age-associated low-grade chronic inflammation contributes to the development of a spectrum of chronic diseases, including diabetes mellitus, ischemic heart disease, stroke, cancer, chronic kidney disease, non-alcoholic fatty liver disease and neurodegenerative diseases, which affect the quality of life of the elderly and influence their life span. This phenomenon is suggested to arise due to the weakening of the regulatory mechanisms of the immune response, and the persistence of exogenous and endogenous (reflecting oxidative cell injury) antigenic challenges, so it is referred to as oxi-inflamm-aging. Considering that the development of age-associated chronic inflammation is "silent", i.e., without clinical signs until the aforementioned complications become apparent, it is important to identify the biomarker(s) or pattern/cluster of biomarkers for this inflammation. It is also important to define new strategies to combat the "silent" damage induced by chronic inflammation. Given that at present there are no reliable biomarkers for chronic inflammation, this review points out the problems in defining biomarker(s) or patterns/clusters of biomarkers for chronic inflammation in order to stimulate further research and points to some possible routes of investigation.
Funder
Ministry of Education, Science and Technological Development of the Republic of Serbia
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Subject
Pharmaceutical Science,Pharmacology
Reference97 articles.
1. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G. Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda). 2008;23:64-74;
2. Roser M, Ortiz-Ospina E, Ritchie H. "Life Expectancy" [Internet]. OurWorldInData.org; 2013 [cited 2022 Feb 2]. Available from: https://ourworldindata.org/life-expectancy;
3. O'Neill A. Life expectancy at birth in Serbia 2019, by gender [Internet]. 2022 [cited 2022 Feb 2]. Available from: https://www.statista.com/statistics/974613/life-expectancy-at-birth-in-serbia-bygender;
4. Nakajima H, Yano K. Examination of Factors Affecting Life Expectancy by Prefecture Based on the Criteria of the Organisation for Economic Co-operation and Development. Nihon Eiseigaku Zasshi. 2020;75(0);
5. Mackenbach JP, Valverde JR, Bopp M, Brønnum-Hansen H, Deboosere P, Kalediene R, et al. Determinants of inequalities in life expectancy: an international comparative study of eight risk factors. Lancet Public Health. 2019;4(10):e529-e537;