Aging of the Immune System as a Prognostic Factor for Human Longevity-Reference-Cited by-同舟云学术

Aging of the Immune System as a Prognostic Factor for Human Longevity

Published:2008-04 Issue:2 Volume:23 Page:64-74
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Larbi Anis¹,Franceschi Claudio²,Mazzatti Dawn³,Solana Rafael⁴,Wikby Anders⁵,Pawelec Graham⁶

Affiliation:

1. University of Tübingen, Center for Medical Research,Tübingen, Germany;

2. Interdepartmental Centre “L. Galvani” (CIG), University of Bologna, and Department of Gerontological Research, Italian National Research Centre on Aging (INRCA), Ancona, Italy;

3. Unilever Corporate Research, Colworth Park, Sharnbrook, United Kingdom;

4. Department of Cellular Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain;

5. Department of Natural Science and Biomedicine, School of Health Sciences, Jönköping University, Jönköping, Sweden; and

6. University of Tübingen, Center for Medical Research, Tübingen, Germany

Abstract

Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00040.2007

Reference126 articles.

1. Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of Phosphoinositide 3-Kinase-Signaling Pathway

2. Dendritic cells in human aging

3. IFN-γ production by CMV-specific CD8+ T cells is high in elderly donors

4. Old Rhesus Macaques Treated with Interleukin-7 Show Increased TREC Levels And Respond Well to Influenza Vaccination

5. T cell development, ageing and Interleukin-7

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