Abstract
Depression, a major global public health concern and leading cause of disability, necessitates effective management. This paper, as part of the development of comprehensive guidelines for the treatment of depressive disorder in Serbia, delves into the pharmacological treatment of treatment-resistant depression (TRD), focusing on augmentative and switching strategies, aiming to address the lack of response to standard treatments. The focus is on the efficacy and tolerability of various pharmacological agents, aimed at facilitating informed clinical decisions. In TRD, augmentation strategies involving atypical antipsychotics, NMDA antagonists, mood stabilizers, and other compounds are examined. Finally, the importance of an individualized approach in deciding between augmentation and switching strategies is emphasized. This narrative review aims to inform treatment guidelines and encourages a collaborative approach, which considers individual patient factors, to improve the quality of care for individuals with treatment-resistant depression.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference57 articles.
1. Mihajlović G, Vojvodić P, Vojvodić J, Andonov A, Hinić D. Validation of the Montgomery-Åsberg depression rating scale in depressed patients in Serbia. Srp Arh Celok Lek. 2021;149(5-6):316-21;
2. Dodd S, Bauer M, Carvalho AF, Eyre H, Fava M, Kasper S, et al. A clinical approach to treatment resistance in depressed patients: What to do when the usual treatments don't work well enough? World J Biol Psychiatry. 2021;22(7):483-94;
3. Medved S, Žaja N, Gazdag G, Lengvenyte A, Mörkl S, Mucci F, et al. Preliminary Assessment of Pre-Electroconvulsive Therapy Evaluation Practices in European Countries: The Need for Guidelines. J ECT. 2022;38(4):230-7;
4. Taylor DM, Barnes TRE, Young AH. The Maudsley prescribing guidelines in psychiatry. John Wiley & Sons; 2021;
5. Gelenberg AJ, Freeman MP, Markowitz JC, Rosenbaum JF, Thase ME, Trivedi MH, et al. American Psychiatric Association practice guidelines for the treatment of patients with major depressive disorder. Am J Psychiatry. 2010;167(Suppl 10):9-118;
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献