The pathophysiological role of intestinal dysbiosis in type 2 diabetes mellitus and the anti-diabetic potential of probiotics, prebiotics and fecal microbiota transplantation-Reference-Cited by-同舟云学术

The pathophysiological role of intestinal dysbiosis in type 2 diabetes mellitus and the anti-diabetic potential of probiotics, prebiotics and fecal microbiota transplantation

Published:2023-05-31 Issue:4-5 Volume:101 Page:188-193
ISSN:2412-1339
Container-title:Clinical Medicine (Russian Journal)
language:
Short-container-title:jour

Author:

Aitbaev K. A.¹^ORCID,Murkamilov I. T.²^ORCID,Murkamilova Zh. A.³^ORCID,Fomin V. V.⁴^ORCID,Kudaibergenova I. O.⁵^ORCID,Yusupova T. F.⁶,Yusupov F. A.⁶

Affiliation:

1. Scientifi c and Research Institute of Molecular Biology and Medicine

2. Kyrgyz State Medical Academy named after I.K. Akhunbaev; Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

3. Kyrgyz-Russian Slavic University named after the First President of Russian Federation B.N. Yeltsin

4. I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

5. Kyrgyz State Medical Academy named after I.K. Akhunbaev

6. Osh State University

Abstract

Type 2 diabetes mellitus (DM2) is a multifactorial disease, and obesity plays the key role in the development thereof. It is believed that the global rise in vast proliferation of DM2 and obesity, recently viewed as an epidemic, is caused by urbanization, reduced physical activity and widely available high-calorie food. Recently, another “player” in the pathophysiology of type 2 diabetes mellitus has been discovered — the intestinal microbiota (IM). Numerous studies have shown the connection between the development of type 2 diabetes mellitus and IM. The review discusses the mechanisms, through which IM contributes to the development of DM2. The results of experimental and clinical studies on the eff ectiveness of the use of probiotics, prebiotics and fecal microbiota transplantation as a method of prevention and treatment of type 2 diabetes mellitus are given.

Publisher

Medical Informational Agency Publishers

Subject

General Medicine

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