Affiliation:
1. National Medical Research Centre of Prevention Medicine of the Ministry of Health
Abstract
Atherosclerosis and osteoporosis until recently were regarded as the diseases of modern society, and their simultaneous development was explained just by the increased chances with longevity. Currently, there are studies showing evidence on these diseases in ancient populations, regardless the age and gender. The diseases found in younger age, with the early Egyptian civilization, witness on the common genetic and behavioral risk factors and pathogenetic components, than simple age-related chance. Scientific publications show more and more data on common properties of these diseases and pathogenetic mechanisms. High risk of premature death from atherosclerosis and osteoporosis complications facilitates the search for individual and general predictors of the disorders with the aim of on-time prevention. Treatment of atherosclerosis and osteoporosis presentation events in one patient demands for a range of medications that leads to polypragmasia. The review is focused on common mechanisms of vascular stiffness development, calcification and bone density decrease. Profound understanding might make it to open novel targets for one drug to both diseases, with decreased rate of complications.
Subject
Cardiology and Cardiovascular Medicine
Reference50 articles.
1. Thompson RC, Allam AH, Lombardi GP, et al. Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations. Lancet. 2013;381(9873):1211-22. doi:10.1016/S0140-6736(13)60598-X.
2. Zaki ME, Hussien FH, Banna RA. Osteoporosis among ancient Egyptians. Int J Osteoarhaeol. 2009;19:78-89.
3. Верткин А. Л. Коморбидный пациент. Руководство для практических врачей. М.: Эксмо. 2015;5:84с. ISBN: 978-5-699-83378-8.
4. Riefkohl EZ, Pharm D, Heather L, et al. Medication and falls in the Elderly: A review of the evidence and practical considerations. P&T. 2003;28(11):724-33.
5. Lampropolos CE, Papaioannou I, D’Cruz DP. Osteoporosis-a risk factor for cardiovascular disease? Nat Rev Rheumatol. 2012;8:587-98. doi:10.1038/nrrheum.2012.120.
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