NEUROPROTECTIVE ACTION OF BUTORPHANOL AND RU-1205 WITH EVALUATION OF THEIR EFFECT O N THE BIOELECTRICAL ACTIVITY OF THE BRAIN IN THE GLOBAL ISCHEMIA MODEL

Abstract

Since ischemic stroke is an extremely common and dangerous pathology, it is important to use drugs with neuroprotective activity. The depth and degree of brain damage due to ischemia are reflected in its bioelectrical activity. This makes it possible to use the electrocorticography or intracranial electroencephalography (EEG) as a tool for evaluating the effectiveness of neuroprotective therapy. In the present study the neuroprotective properties of the experimental compound RU-1205 and the kappa-opioid agonist butorphanol were analyzed. The neuroprotective effect of the substances was assessed by measuring the extent of the neurological deficit and the changes in bioelectrical activity of the ischemic brain of rats. Compound RU-1205 (10 mg/kg, i.v.) as well as the reference drug butorphanol (2,5 mg/kg, i.v.) restored to normal neurological status and power of the EEG signal in delta and theta frequency bands.