Apple pomace extract: photochemopreventive action against UVA radiation in a cell culture model

Abstract

Apple pomace, a byproduct from juice industry, can be used as a valuable nutraceutical, hence its phenolic compounds, including rutin, are powerful antioxidants. This work evidence the extract enriched with apple polyphenols from apple pomace using ethanol: water as solvent and partitioned with ethyl acetate (1:1 w/w), where its lyophilized product was evaluated for its photochemopreventive action on MRC-5 fibroblasts against a harmful UVA radiation dose. The enriched apple pomace extract was able to promote photochemopreventive action against UVA radiation, decreasing cell death and the lipid peroxidation formation. Therefore, the optimized extraction process may make the apple pomace application viable as a source of bioactive extracts with photochemopreventive action against ultraviolet radiation to the use in dermal formulations.