A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep
Author:
Affiliation:
1. Department of Pediatrics; Perinatal Research Center; University of Colorado Denver School of Medicine; Aurora Colorado
2. Center for Developmental Health; Knight Cardiovascular Institute; Oregon Health & Science University; Portland Oregon
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Publisher
Wiley
Subject
Physiology (medical),Physiology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.14814/phy2.13840/fullpdf
Reference45 articles.
1. IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice;Agudo;Diabetologia,2008
2. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus;Andrews;Endocrinology,2015
3. The pregnant sheep as a model for human pregnancy;Barry;Theriogenology,2008
4. Fetal growth and placental function;Bauer;Mol. Cell. Endocrinol.,1998
5. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep;Benjamin;Am. J. Physiol. Regul. Integr. Comp. Physiol.,2017
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1. IGF-1 infusion increases growth in fetal sheep when euinsulinemia is maintained;Journal of Endocrinology;2024-05-09
2. Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets;Journal of Developmental Origins of Health and Disease;2023-04-28
3. Changes in microvascular perfusion of heart and skeletal muscle in sheep around the time of birth;Experimental Physiology;2022-11-24
4. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep;Frontiers in Physiology;2022-08-25
5. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect;American Journal of Physiology-Endocrinology and Metabolism;2021-06-01
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