Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect-Reference-Cited by-同舟云学术

Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect

Published:2021-06-01 Issue:6 Volume:320 Page:E1138-E1147
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

White Alicia¹^ORCID,Stremming Jane¹^ORCID,Boehmer Brit H.¹,Chang Eileen I.¹,Jonker Sonnet S.²^ORCID,Wesolowski Stephanie R.¹,Brown Laura D.¹^ORCID,Rozance Paul. J.¹

Affiliation:

1. Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado

2. Knight Cardiovascular Institute, Center for Developmental Health, Oregon Health & Science University, Portland, Oregon

Abstract

After a 1-wk infusion of IGF-1 LR3, late gestation fetal sheep had lower plasma insulin and glucose concentrations, reduced fetal glucose-stimulated insulin secretion, and decreased fractional insulin secretion from isolated fetal islets without differences in pancreatic insulin content.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00623.2020

Reference57 articles.

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2. The Insulin-like Growth Factors and feto-placental Growth

3. Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation