Simulated microgravity increases <scp>CD226</scp>+<scp>Lin−CD117−Sca1</scp>+ mesenchymal stem cells in mice-Reference-Cited by-同舟云学术

Simulated microgravity increases CD226⁺Lin⁻CD117⁻Sca1⁺ mesenchymal stem cells in mice

Published:2024-03 Issue:5 Volume:12 Page:
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiological Reports

Author:

Zhou Wenjing¹²,Li Yi²³,Hou Yongli²,Dan Wenli²,Chen Lihua²,Shi Fei⁴,Zhao Fang⁵,Fang Liang²^ORCID

Affiliation:

1. College of Life Sciences, Northwest University Xi’ an China

2. Department of Immunology Fourth Military Medical University Xi'an China

3. Medical School of Yan'an University Yan'an China

4. The Key Laboratory of Aerospace Medicine, Ministry of Education Fourth Military Medical University Xi'an China

5. Department of Occupational and Environmental Health, The Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health, Fourth Military Medical University Xi'an China

Abstract

AbstractMicrogravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226+Lin−CD117−Sca1+ MSCs. The CD226+ MSCs produced higher IL‐6, M‐CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases.

Funder

National Natural Science Foundation of China

Fourth Military Medical University

Publisher

Wiley

Link

https://physoc.onlinelibrary.wiley.com/doi/pdf/10.14814/phy2.15971

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