THE RATIONALE FOR THE USE OF INDICES OF A NON-SPECIFIC LINK OF PATHOGENESIS AND THE DOSE OF LOCAL VIBRATION WHEN PREDICTING THE RISK OF DEVELOPING A VIBRATIONAL DISEASE

Abstract

Introduction. The importance of attracting to predict the development of hand-arm vibration syndrome (HAVS) nonspecific indices of violations of the basic functional systems, for which the dose or exposure dependences can be clearly established, is shown. There is shown the importance of attracting non-specific indices of violations of the main functional systems of the body, for which dose or exposure dependencies can be clearly established to predict the development of vibrational disease (VD) due to a local vibration. Material and methods. The studies were carried out on the information array of personalized indices of the functional systems in aircraft production workers exposed to local vibration. There was used a multiplicity of exceeding the maximum dose of vibration as an index of the vibration effect during the work. Information-entropy modeling was used to predict the risk of changes in functional systems formation. Results. Analysis of calculations in different variants of diagnostic models allowed drawing a conclusion that the pathological indices of the main activity of the brain and thyroid system made the greatest contribution (82.6%) to HAVS formation among the studied combinations. In the model with the consideration of the indices of the main activity of the brain and the thyroid system, an increase in the equivocation of the system to almost 100% were and by 3 times increasing differences between the coefficients of redundancy characterizing the relative organization of the system in the norm and pathology were noted. Conclusion. The conducted studies have allowed substantiating the high importance of non-specific indices of the pathogenesis of HAVS (Central nervous system and thyroid systems), which opens up opportunities to attract them to the structure of the model, taking into account the dose of local vibration. It is proposed to consider the expansion of the information base with the involvement in the model, along with indices of the specific link of the pathogenesis of HAVS and indices of its nonspecific link.