The influence of chemical environmental factors on functions and interrelationships of regulatory systems in children

Abstract

In children under aerotechnogenic impact of phenol, methanol and formaldehyde, these substances are identified in the blood in significantly higher concentrations than in the unexposed group. There was found the activation of the mechanisms of the innate immunity (phagocytic activity) and inhibition of markers of the acquired immunity (reduction of relative indices of the content of T-lymphocytes (CD3+) and their subsets (CD4+- and CD8+-lymphocytes). Out of the markers of neuroendocrine regulation there was proved the significant decline of cortisol. Under the impact of anthropogenic chemical environmental factors there are occurred rearrangement and the transformation of interactions within the neuroendocrine and immune systems, as well as “early”, not manifested yet in the nature of specific nosological forms, but over time having the possibility to lead to the shaping of various pathology changes in the neuroendocrine regulation of the immune system.