Affiliation:
1. School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
Abstract
A catalyst-free, solvent-promoted and scalable three-component Mannich-type reaction of indoles, aromatic aldehydes and secondary amines for the synthesis of 3-(1-dialkylaminoalkyl)-1H-indoles has been developed. The protocol provided a mild, simple and highly atom-economic alternative to prepare the title compounds, and the corresponding products could be obtained in good to excellent yields in most cases.
Cited by
8 articles.
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