Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via a Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities-Reference-Cited by-同舟云学术

Catalyst-free and multicomponent synthesis of 3-aminoalkylated indoles via a Mannich-type reaction: multitargeted anticancer, tyrosinase and α-glucosidase inhibitory activities

Published:2021 Issue:38 Volume:45 Page:18183-18191
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Huynh Thi-Kim-Chi¹²,Ngo Kim-Khanh-Huy³,Nguyen Hoang-Phuc¹³,Dang Hoai-Khanh³,Phung Van-Trung⁴,Thai Khac-Minh⁵,Hoang Thi-Kim-Dung¹²^ORCID

Affiliation:

1. Institute of Chemical Technology – VAST, 1A Thanh Loc 29 Str., Dist. 12, Ho Chi Minh City, Vietnam

2. Graduate University of Science and Technology – VAST, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam

3. Ton Duc Thang University, 19 Nguyen Huu Tho Str., Dist. 7, Ho Chi Minh City, Vietnam

4. Center for Research and Technology Transfer – VAST, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam

5. Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41–43 Dinh Tien Hoang Str., Dist. 1, Ho Chi Minh City, Vietnam

Abstract

3-Aminoalkylated indoles, synthesized via a multicomponent Mannich-like reaction, are evaluated for enzyme inhibition; 5e and 5f are shown to be prospective multitargeted anticancer agents, and the cytotoxic mechanism of action is demonstrated via molecular docking study.

Funder

National Foundation for Science and Technology Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ02536H

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