Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2- c]chromene-3-carbonitrile-Reference-Cited by-同舟云学术

Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2- c]chromene-3-carbonitrile

Published:2013-03-01 Issue:3 Volume:68 Page:229-238
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Al-Masoudi Najim A.¹,Mohammed Hamid H.²³,Hamdy Aws M.²,Akrawi Omer A.²,Eleya Nadi²,Spannenberg Anke⁴,Pannecouque Christophe⁵,Langer Peter²⁴

Affiliation:

1. Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq. Present address: Am Tannenhof 8, 78464 Konstanz, Germany

2. Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany

3. Department of Chemistry, College of Science, University of Al-Mustansiryah, Baghdad, Iraq

4. Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock, Germany

5. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Abstract

A new series of pyrano-chromene and pyrimido pyrano-chromene derivatives were synthesized starting from 2-amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (6). The structures of the synthesized compounds were elucidated by spectral data. Compounds 6-11, 13-15 and 18 have been selected for an inhibitory activity screening against HIV-1 and HIV-2 in MT-4 cells.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.5560/znb.2013-2297/pdf

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