Affiliation:
1. Tolani College of Arts & Science, Adipur, Gujarat, India
Abstract
An efficient Synthesis of a novel series of N,7-bis(substitutedphenyl)-4,7-dihydro-5-isopropyl-[1,2,4]triazolo-[1,5-a]pyrimidine-6-carboxamide (4a-j) was accomplished from N-(substituedphenyl)-4-methyl-3-oxopentanamide, 3-amino-1,2,4-triazole and different aldehyde reflex 20 min with DMF and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.
Reference17 articles.
1. Butler T, Maravent S, Boisselle J, Valdes J, Fellner C. A review of 2014 cancer drug approvals, with a look at 2015 and beyond. Pharmacol Ther 2015; 40: 191–205.
2. Pogorelcnik B, Brvar M, Zegura B, Filipic M, Solmajer T, Perdih A. Discovery of mono- and disubstituted 1Hpyrazolo[3,4]pyrimidines and 9H-purines as catalytic inhibitors of human DNA topoisomerase IIalpha. Chem Med Chem 2015; 10: 345–59.
3. Mohamed AM, El-Sayed WA, Alsharari MA, Al-Qalawi HR, Germoush MO. Anticancer activities of some newly synthesized pyrazole and pyrimidine derivatives. Arch. Pharm. Res. 2013; 36: 1055–65.
4. Al-Mohizea AM, Al-Omar MA, Abdalla MM, Amr AG. alphareductase inhibitors, antiviral and anti-tumor activities of some steroidal cyanopyridinone derivatives. Int J Biol Macromol 2012; 50: 171–79.
5. Al-Harbi NO, Bahashwan SA, Fayed AA, MS, Amr A, G. Antiparkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates. Int J Biol Macromol 2013; 57: 165–73.