Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA Topoisomerase IIα-Reference-Cited by-同舟云学术

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Discovery of Mono- and Disubstituted 1H-Pyrazolo[3,4]pyrimidines and 9H-Purines as Catalytic Inhibitors of Human DNA Topoisomerase IIα

Published:2014-12-17 Issue:2 Volume:10 Page:345-359
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Pogorelčnik Barbara,Brvar Matjaž,Žegura Bojana,Filipič Metka,Solmajer Tom,Perdih Andrej

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference66 articles.

1. Clinical applications of anticancer drugs targeted to topoisomerase II

2. DNA topology: Topoisomerases keep it simple

3. DNA Topoisomerases: Structure, Function, and Mechanism

4. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

5. Recent Developments of DNA Poisons - Human DNA Topoisomerase IIα Inhibitors - as Anticancer Agents

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1. Molecular choreography: Unveiling the dynamic landscape of type IIA DNA topoisomerases before T-segment passage through all-atom simulations;International Journal of Biological Macromolecules;2024-06

2. Nature-inspired substituted 3-(imidazol-2-yl) morpholines targeting human topoisomerase IIα: Dynophore-derived discovery;Biomedicine & Pharmacotherapy;2024-06

3. Virtual screening and multilevel precision-based prioritisation of natural inhibitors targeting the ATPase domain of human DNA topoisomerase II alpha;Journal of Biomolecular Structure and Dynamics;2023-03-10

4. An insight into the rational design of recent purine-based scaffolds in targeting various cancer pathways;Journal of Molecular Structure;2023-02

5. The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7);RSC Advances;2023

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