Glucarpidase for the management of elevated methotrexate levels in patients with impaired renal function

Author:

Fermiano Mariana1,Bergsbaken Jason2,Kolesar Jill M.1

Affiliation:

1. State University of Campinas, Sao Paulo, Brazil.

2. University of Wisconsin (UW) Hospital and Clinics, Madison.

Publisher

Oxford University Press (OUP)

Subject

Health Policy,Pharmacology

Reference19 articles.

1. Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia;Csordas;Anticancer Drugs,2013

2. Glucarpidase to combat toxic levels of methotrexate in patients;Green;Ther Clin Risk Manag,2012

3. LaCasce AS, for UpToDate, Inc. Therapeutic use and toxicity of high-dose methotrexate. www.uptodate.com/contents/therapeutic-use-and-toxicity-of-high-dose-methotrexate (accessed 2014 Feb 12).

4. Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy;Schwartz;Oncologist,2007

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