Affiliation:
1. Saratov State Medical University
Abstract
Objective: to define bone mineral density and bone turnover indicators in primary osteoarthrosis accompanied with osteodeficiency conditions of varying severity as a means of early osteoarthrosis detection in individuals. Review method. We analyzed 157 Russian and foreign studies of 2005-2022 retrieved from e-Library, Medline, PubMed, PubMed Central, Google Scholar, SpringerLink и Elsevier. The keyword search in Russian and English involved "primary osteoarthritis", "osteoporosis", "osteopenia", "bone mineral density", "markers of bone resorption", "bone formation markers", "bone metabolism regulators", "RANKL/RANK/OPG system". 35 studies were considered the most valuable and eventually reviewed. Conclusion. The analysis suggested that primary osteoarthrosis accompanied by osteodeficiency conditions can be assessed by determining bone mineral density, bone turnover indicators as well as bone turnover regulators.
Publisher
LLC Science and Innovations
Reference35 articles.
1. Novakov VB, Novakova ON, Churnosov Ml. Risk factors and molecular entities of the etiopathogenesis of the knee osteo-arthritis (literature review). Genij Ortopedii. 2021; 27 (1): 112-20. DOI: 10.18019/1028-4427-2021-27-1-112-120
2. Puchinyan DM, Gladkova EV, Karyakina EV, et al. Pathogenic specifics of articular cartilage metabolism regulation at the initial stage of gonarthrosis. Saratov Journal of Medical Scientific Research. 2019; 15 (4): 939-43.
3. Hu W, Chen Y, Dou C, et al. Microenvironment in subchondral bone: Predominant Regulator for the treatment of osteoarthritis. Ann Rheum Dis. 2020; 80 (4): 413-22. DOI: 10.1136/an-nrheumdis-2020-218089
4. Ignatiev AM, Turchin Nl. Instrumental and biochemical indicators of the bone tissue state in osteomalacia and osteoporosis. Trauma. 2020; 21 (6): 16-20. DOI: 10.22141/1608-1706.6.21.2020.223883
5. Bairamov АА, Maevsky El, Zelener АО, et al. Bone remodeling processes at the stages of correction of experimentally induced osteoporosis. Novgorod State University Bulletin. 2020; 1 (117): 23-9. DOI:10.34680/2076-8052.2020.1 (117).23-29