Treatment with the arginase inhibitor N ω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

Author:

Bagnost Teddy,Berthelot Alain,Bouhaddi Malika,Laurant Pascal,André Claire,Guillaume Yves,Demougeot Céline

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology,Internal Medicine

Reference42 articles.

1. Comparative properties of arginases;Jenkinson;Comp Biochem Physiol,1996

2. Arginase activity in endothelial cells: inhibition by N ω-hydroxy-L-arginine during high-output NO production;Buga;Am J Physiol,1996

3. Role of arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation;Ignarro;Proc Natl Acad Sci U S A,2001

4. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric-oxide-mediated vasodilatory function;Zhang;FASEB J,2001

5. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels;Berkowitz;Circulation,2003

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