Letting the Gene out of the Bottle
Author:
Affiliation:
1. From the Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania (I.B., E.E.Y.); and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada (L.D.).
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Anesthesiology and Pain Medicine
Link
http://pubs.asahq.org/anesthesiology/article-pdf/121/4/678/264811/20141000_0-00009.pdf
Reference15 articles.
1. OPRM1 A118G gene variant and postoperative opioid requirement: A systematic review and meta-analysis.;Anesthesiology,2014
2. Single-nucleotide polymorphism in the human μ-opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction.;Proc Natl Acad Sci U S A,1998
3. A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling.;J Biol Chem,2001
4. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human μ-opioid receptor.;J Neurochem,2004
5. Allelic expression imbalance of human μ-opioid receptor (OPRM1) caused by variant A118G.;J Biol Chem,2005
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