Affiliation:
1. From the Department of Family Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea (I.C.H.); Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea (J.-Y.P.); Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang, Republic of Korea (S.-K.M.); Department of Statistics, Dongg
Abstract
Abstract
Background:
Although a number of studies have investigated the association of the OPRM1 A118G polymorphism with pain response, a consensus has not yet been reached.
Methods:
The authors searched PubMed, EMBASE, and the Cochrane Library to identify gene-association studies that explored the impact of the OPRM1 A118G polymorphism on postoperative opioid requirements through July 2013. Two evaluators independently reviewed and selected articles on the basis of prespecified selection criteria. The authors primarily investigated the standardized mean difference (SMD) of required amounts of opioids between AA homozygotes and G-allele carriers. The authors also performed subgroup analyses for race, opioid use, and type of surgery. Potential bias was assessed using the Egger’s test with a trim and fill procedure.
Results:
Three hundred forty-six articles were retrieved from databases, and 18 studies involving 4,607 participants were included in the final analyses. In a random-effect meta-analysis, G-allele carriers required a higher mean opioid dose than AA homozygotes (SMD, −0.18; P = 0.003). Although there was no evidence of publication bias, heterogeneity was present among studies (I2 = 66.8%). In the subgroup meta-analyses, significance remained robust in Asian patients (SMD, −0.21; P = 0.001), morphine users (SMD, −0.29; P <0.001), and patients who received surgery for a viscus (SMD, −0.20; P = 0.008).
Conclusions:
The OPRM1 A118G polymorphism was associated with interindividual variability in postoperative response to opioids. In a subpopulation, identifying OPRM1 A118G polymorphism may provide valuable information regarding the individual analgesic doses that are required to achieve satisfactory pain control.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Anesthesiology and Pain Medicine
Reference74 articles.
1. Evolving knowledge of opioid genetics in cancer pain.;Clin Oncol (R Coll Radiol),2011
2. Pharmacogenetics of opioids.;Clin Pharmacol Ther,2007
3. Consequences of the 118A>G polymorphism in the OPRM1 gene: Translation from bench to bedside?;J Pain Res,2013
4. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor.;J Neurochem,2004
5. The single nucleotide polymorphism A118G alters functional properties of the human μ opioid receptor.;J Neurochem,2007
Cited by
117 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献